The Fast Facts
- Yucca Health is a telehealth platform that pairs you with licensed U.S. providers for compounded GLP-1 weight-loss treatment — no in-person clinic visits.
- It offers compounded semaglutide and tirzepatide (each with a B12 boost), plus NAD+ for longevity and Sermorelin for recovery.
- Orders ship free via UPS 2-Day Air, buy-now-pay-later is available, and Yucca holds a 4.6/5 Trustpilot score across 1,000+ reviews and LegitScript certification.
Yucca Health is one of the fast-growing online GLP-1 weight-loss platforms, offering compounded semaglutide and tirzepatide through licensed U.S. providers and pharmacies — with no in-person clinic visits. In this Yucca Health review, we break down how it works, what it costs, the trade-offs of compounded GLP-1s, and who it suits.
A well-supported, transparent online GLP-1 program with free 2-day shipping and strong reviews. Best for people who want provider-guided semaglutide or tirzepatide delivered to their door.
A quick look at our picks
- Best overall GLP-1: Yucca Semaglutide+
- Strongest for stalled weight loss: Yucca Tirzepatide+
- Longevity add-on: Yucca NAD+
- Muscle recovery: Yucca Sermorelin
What is Yucca Health?
Yucca Health is a telehealth platform that connects patients with licensed U.S. providers and pharmacies for personalized, compounded weight-loss treatment. You complete a short online intake, a licensed provider reviews your history (usually within 24 hours), and if you’re approved, a compounded prescription is filled by a licensed U.S. pharmacy and shipped to your door. Beyond weight loss, Yucca also offers NAD+ (longevity) and Sermorelin (muscle recovery), with peptides listed as coming soon.
The company says it serves 20,000+ patients, holds a 4.6/5 Trustpilot score across 1,000+ reviews, and displays LegitScript certification along with HIPAA-compliant and “compounded in the USA” badges.
Yucca products we reviewed
Yucca offers four provider-prescribed treatments. Here’s an honest look at each — what it is, who it suits, and what it costs.
Yucca Semaglutide+
- Medication: compounded semaglutide (same active ingredient as Wegovy® / Ozempic®)
- Dosing: once-weekly injection, plus a B12 boost
- Best for: steady, appetite-driven weight loss
- Price: as low as $146/mo on the 6-month plan
Our review
Semaglutide+ is Yucca’s most popular option and the natural starting point for most people. It uses the same active ingredient found in Wegovy® and Ozempic® to curb appetite and support gradual weight loss, with an added B12 boost aimed at energy. Pricing starts around $175 for the first month on a monthly plan and drops to about $146/mo if you commit to the six-month plan.
It’s a strong fit if you’re new to GLP-1s and want a well-reviewed, provider-guided route without visiting a clinic.
Product details
- Shipping: free UPS 2-Day Air
- Providers: licensed U.S., all 50 states
- Payments: Klarna / Affirm / Afterpay
- FDA-approved: no (compounded)
Yucca Tirzepatide+
- Medication: compounded tirzepatide (active ingredient in Zepbound® / Mounjaro®)
- Dosing: once-weekly injection, plus a B12 boost
- Best for: stronger appetite control, or when semaglutide stalls
- Price: as low as $258/mo on the 6-month plan
Our review
Tirzepatide+ is Yucca’s strongest weight-loss option. As a dual GIP/GLP-1 medication, it targets appetite and blood-sugar control through two pathways, which many people find more powerful than semaglutide alone. It also includes a B12 boost. It costs more — from about $258/mo on the six-month plan — but it’s the option to consider if semaglutide results plateau.
Product details
- Shipping: free UPS 2-Day Air
- Providers: licensed U.S., all 50 states
- Payments: Klarna / Affirm / Afterpay
- FDA-approved: no (compounded)
Yucca NAD+
- Category: longevity / cellular-health injection
- Focus: energy, focus, and healthy aging
- Note: this is a wellness add-on, not a weight-loss medication
- Price: as low as $215
Our review
NAD+ sits outside Yucca’s weight-loss lineup. It’s a longevity-focused injection meant to support energy, focus, and healthy aging at the cellular level. If anti-aging and daily vitality are your goals — rather than weight loss — it’s a reasonable add-on, though the evidence base for NAD+ therapy is still emerging. Pricing starts around $215 and is confirmed after your intake review.
Yucca Sermorelin
- Category: growth-hormone–supporting peptide
- Focus: recovery, performance, sleep, and body composition
- Best for: active, fitness-minded adults
- Price: as low as $199
Our review
Sermorelin is a niche option aimed at active adults rather than general weight loss. As a growth-hormone–supporting peptide, it’s marketed for recovery, performance, sleep quality, and body composition. It’s the most specialized product in Yucca’s catalog, so it suits fitness-focused users who already understand what they’re looking for. Pricing starts around $199, confirmed after intake.
How Yucca works
- Complete your intake — a short online medical questionnaire.
- Choose your plan and check out.
- Verify your identity for compliance.
- Provider review — a licensed U.S. provider reviews your intake, typically within 24 hours.
- Receive your medication — compounded by a licensed U.S. pharmacy and shipped via UPS 2-Day Air.
- Start treatment and ongoing care — with onboarding support and full patient-portal access.
Pros and cons of Yucca at a glance
Pros
- competitive 6-month pricing on both semaglutide and tirzepatide
- free UPS 2-Day Air shipping on all orders
- B12 boost included with GLP-1 treatments
- licensed U.S. providers in all 50 states
- strong Trustpilot and Google ratings; LegitScript-certified
- buy-now-pay-later options (Klarna, Affirm, Afterpay)
Cons
- medications are compounded and not FDA-approved
- the lowest prices require a 6-month commitment
- final pricing is only shown after intake
- compounded GLP-1 availability can shift with changing FDA rules
How much does Yucca cost?
Yucca is transparent that final pricing is confirmed after intake once you’re eligible, but published starting prices are competitive for the compounded telehealth space: semaglutide as low as $146/mo and tirzepatide as low as $258/mo on the six-month plan (monthly plans start higher, around $175 for the first month of semaglutide). NAD+ starts around $215 and Sermorelin around $199. Free UPS 2-Day Air shipping is included on all orders, and buy-now-pay-later options are available. As always, the lowest prices require the longer 6-month commitment.
Yucca vs other online GLP-1 programs
| Program | Medications | Care model | Stands out for |
|---|---|---|---|
| Yucca (this review) | Semaglutide, tirzepatide (+ B12), NAD+, Sermorelin | Licensed U.S. providers, compounded, UPS 2-day | Free 2-day shipping + strong reviews + BNPL |
| Gala | Semaglutide, tirzepatide, microdosing | Fully online program with licensed providers | Gentle microdosing start option |
| Shed | Wide menu incl. brand-name and oral | Telehealth, flexible formats | The most format options + refund promise |
| Sunlight | Semaglutide, tirzepatide | Telehealth, unlimited provider messaging | Unlimited provider support between visits |
Pricing changes often and depends on medication and dose. Always check the current price on each provider site before signing up.
Understanding compounded GLP-1s
Like most GLP-1 telehealth services, Yucca provides compounded semaglutide and tirzepatide. Compounded medications contain the same active pharmaceutical ingredients as brand-name drugs and are prepared by licensed U.S. pharmacies, but they are not FDA-approved and do not undergo FDA review for safety, effectiveness, or manufacturing quality. Compounding rules have also tightened in 2026, so availability can change. This is standard across the compounded telehealth category — but it’s an important trade-off to understand before you start.
Safety and side effects
GLP-1 medications commonly cause nausea, diarrhea, constipation, and reduced appetite, especially when starting or increasing a dose. Serious risks are less common but real, which is why provider oversight matters. Yucca requires a licensed-provider review before treatment and offers ongoing support through its patient portal. This is not medical advice — always discuss your history, medications, and any side effects with a qualified healthcare provider.
Who Yucca is best for
Yucca is a strong fit if you want a straightforward, well-reviewed online route to semaglutide or tirzepatide, value fast free shipping, and like the option to spread payments with Klarna, Affirm, or Afterpay. It’s less ideal if you specifically want brand-name, FDA-approved medication or prefer not to commit to a 6-month plan for the best price.
Frequently asked questions about Yucca Health
Is Yucca Health legit?
Yucca is a LegitScript-certified telehealth platform that works with licensed U.S. providers and pharmacies, and it holds a 4.6/5 Trustpilot rating across 1,000+ reviews.
Are Yucca’s medications FDA-approved?
No. Yucca provides compounded semaglutide and tirzepatide, which use the same active ingredients as brand-name drugs but are not FDA-approved.
How fast does Yucca ship?
Approved orders are compounded by a licensed U.S. pharmacy and shipped via free UPS 2-Day Air.
Do I qualify?
Eligibility is typically a BMI of 30+, or 27+ with a weight-related condition, as determined by a licensed provider during your intake review.
The takeaway
Yucca Health is a competitive, well-supported option in the online GLP-1 space — with both semaglutide and tirzepatide, free 2-day shipping, flexible payments, and strong customer ratings. The main trade-off is the same one that applies across the category: the medications are compounded and not FDA-approved. If that fits your comfort level, Yucca is well worth a closer look.
Disclaimer
This article is for informational purposes only and is not medical advice. GLP-1 medications are prescription treatments that require evaluation by a licensed provider; compounded medications are not FDA-approved to diagnose, treat, or prevent any condition. Consult a healthcare professional before starting any weight-loss medication, especially if you are pregnant, nursing, or taking other medications. Details and pricing may change; verify on the provider’s official site. This article may contain affiliate links, and all brand names belong to their respective owners.
